Prior and Novel Coronaviruses, COVID-19, and Human Reproduction: What Is Known?
Identifieur interne : 000104 ( Main/Exploration ); précédent : 000103; suivant : 000105Prior and Novel Coronaviruses, COVID-19, and Human Reproduction: What Is Known?
Auteurs : James Segars [États-Unis] ; Quinton Katler [Géorgie (pays)] ; Dana B. Mcqueen [États-Unis] ; Alexander Kotlyar [États-Unis] ; Tanya Glenn [États-Unis] ; Zac Knight [États-Unis] ; Eve C. Feinberg [États-Unis] ; Hugh S. Taylor [États-Unis] ; James P. Toner [Géorgie (pays)] ; Jennifer F. Kawwass [Géorgie (pays)]Source :
- Fertility and Sterility [ 0015-0282 ] ; 2020.
Abstract
To summarize current understanding of the effects of novel and prior coronaviruses on human reproduction, specifically male and female gametes, and in pregnancy.
Review of English publications in PubMed and Embase to April 6, 2020.
Manuscripts were screened for reports including coronavirus, reproduction, including pathophysiology and pregnancy.
None.
Reproductive outcomes; effects on gametes; pregnancy outcomes; neonatal complications.
Seventy-nine reports formed the basis of the review. Coronavirus binding to cells involves the S1 domain of the spike protein to receptors present in reproductive tissues, including angiotensin converting enzyme-2 (ACE2), CD26, Ezrin, and cyclophilins. SARS-CoV-1 may cause severe orchitis leading to germ cell destruction in males. Reports indicate decreased sperm concentration and motility for 72-90 days following COVID-19 infection. Gonadotropin-dependent expression of ACE2 was found in human ovaries, but it is unclear whether SARS-CoV-2 adversely affects female gametogenesis. Evidence suggests that COVID-19 infection has a lower maternal case fatality rate than SARS or MERS, but anecdotal reports suggest that infected, asymptomatic women may develop respiratory symptoms postpartum. COVID-19 infections in pregnancy are associated with preterm delivery. Postpartum neonatal transmission from mother to child has been reported.
COVID-19 infection may adversely affect some pregnant women and their offspring. Additional studies are needed to assess effects of SARS-CoV-2 infection on male and female fertility.
Url:
DOI: 10.1016/j.fertnstert.2020.04.025
PubMed: 32106972
PubMed Central: 7161522
Affiliations:
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Mcqueen</name><affiliation wicri:level="2"><nlm:aff id="aff3">Division of Reproductive Endocrinology &, Infertility, Department of Obstetrics & Gynecology, Northwestern University, Chicago, Illinois</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Division of Reproductive Endocrinology &, Infertility, Department of Obstetrics & Gynecology, Northwestern University, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Kotlyar, Alexander" sort="Kotlyar, Alexander" uniqKey="Kotlyar A" first="Alexander" last="Kotlyar">Alexander Kotlyar</name><affiliation wicri:level="2"><nlm:aff id="aff4">Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven</wicri:cityArea></affiliation></author><author><name sortKey="Glenn, Tanya" sort="Glenn, Tanya" uniqKey="Glenn T" first="Tanya" last="Glenn">Tanya Glenn</name><affiliation wicri:level="2"><nlm:aff id="aff4">Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven</wicri:cityArea></affiliation></author><author><name sortKey="Knight, Zac" sort="Knight, Zac" uniqKey="Knight Z" first="Zac" last="Knight">Zac Knight</name><affiliation wicri:level="2"><nlm:aff id="aff5">American Society of Reproductive Medicine, Birmingham, Alabama</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Alabama</region></placeName><wicri:cityArea>American Society of Reproductive Medicine, Birmingham</wicri:cityArea></affiliation></author><author><name sortKey="Feinberg, Eve C" sort="Feinberg, Eve C" uniqKey="Feinberg E" first="Eve C." last="Feinberg">Eve C. Feinberg</name><affiliation wicri:level="2"><nlm:aff id="aff3">Division of Reproductive Endocrinology &, Infertility, Department of Obstetrics & Gynecology, Northwestern University, Chicago, Illinois</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Division of Reproductive Endocrinology &, Infertility, Department of Obstetrics & Gynecology, Northwestern University, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Taylor, Hugh S" sort="Taylor, Hugh S" uniqKey="Taylor H" first="Hugh S." last="Taylor">Hugh S. Taylor</name><affiliation wicri:level="2"><nlm:aff id="aff4">Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven</wicri:cityArea></affiliation></author><author><name sortKey="Toner, James P" sort="Toner, James P" uniqKey="Toner J" first="James P." last="Toner">James P. Toner</name><affiliation wicri:level="1"><nlm:aff id="aff2">Division of Reproductive Endocrinology and Infertility, Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia</nlm:aff><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Division of Reproductive Endocrinology and Infertility, Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Kawwass, Jennifer F" sort="Kawwass, Jennifer F" uniqKey="Kawwass J" first="Jennifer F." last="Kawwass">Jennifer F. Kawwass</name><affiliation wicri:level="1"><nlm:aff id="aff2">Division of Reproductive Endocrinology and Infertility, Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia</nlm:aff><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Division of Reproductive Endocrinology and Infertility, Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author></analytic><series><title level="j">Fertility and Sterility</title><idno type="ISSN">0015-0282</idno><idno type="eISSN">1556-5653</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Structured Abstract</title><sec><title>Objective</title><p>To summarize current understanding of the effects of novel and prior coronaviruses on human reproduction, specifically male and female gametes, and in pregnancy.</p></sec><sec><title>Design</title><p>Review of English publications in PubMed and Embase to April 6, 2020.</p></sec><sec><title>Methods</title><p>Manuscripts were screened for reports including coronavirus, reproduction, including pathophysiology and pregnancy.</p></sec><sec><title>Intervention(s)</title><p>None.</p></sec><sec><title>Main Outcome Measure(s)</title><p>Reproductive outcomes; effects on gametes; pregnancy outcomes; neonatal complications.</p></sec><sec><title>Results</title><p>Seventy-nine reports formed the basis of the review. Coronavirus binding to cells involves the S1 domain of the spike protein to receptors present in reproductive tissues, including angiotensin converting enzyme-2 (ACE2), CD26, Ezrin, and cyclophilins. SARS-CoV-1 may cause severe orchitis leading to germ cell destruction in males. Reports indicate decreased sperm concentration and motility for 72-90 days following COVID-19 infection. Gonadotropin-dependent expression of ACE2 was found in human ovaries, but it is unclear whether SARS-CoV-2 adversely affects female gametogenesis. Evidence suggests that COVID-19 infection has a lower maternal case fatality rate than SARS or MERS, but anecdotal reports suggest that infected, asymptomatic women may develop respiratory symptoms postpartum. COVID-19 infections in pregnancy are associated with preterm delivery. Postpartum neonatal transmission from mother to child has been reported.</p></sec><sec><title>Conclusion</title><p>COVID-19 infection may adversely affect some pregnant women and their offspring. Additional studies are needed to assess effects of SARS-CoV-2 infection on male and female fertility.</p></sec></div></front></TEI><affiliations><list><country><li>Géorgie (pays)</li><li>États-Unis</li></country><region><li>Alabama</li><li>Connecticut</li><li>Illinois</li><li>Maryland</li></region></list><tree><country name="États-Unis"><region name="Maryland"><name sortKey="Segars, James" sort="Segars, James" uniqKey="Segars J" first="James" last="Segars">James Segars</name></region><name sortKey="Feinberg, Eve C" sort="Feinberg, Eve C" uniqKey="Feinberg E" first="Eve C." last="Feinberg">Eve C. Feinberg</name><name sortKey="Glenn, Tanya" sort="Glenn, Tanya" uniqKey="Glenn T" first="Tanya" last="Glenn">Tanya Glenn</name><name sortKey="Knight, Zac" sort="Knight, Zac" uniqKey="Knight Z" first="Zac" last="Knight">Zac Knight</name><name sortKey="Kotlyar, Alexander" sort="Kotlyar, Alexander" uniqKey="Kotlyar A" first="Alexander" last="Kotlyar">Alexander Kotlyar</name><name sortKey="Mcqueen, Dana B" sort="Mcqueen, Dana B" uniqKey="Mcqueen D" first="Dana B." last="Mcqueen">Dana B. Mcqueen</name><name sortKey="Taylor, Hugh S" sort="Taylor, Hugh S" uniqKey="Taylor H" first="Hugh S." last="Taylor">Hugh S. Taylor</name></country><country name="Géorgie (pays)"><noRegion><name sortKey="Katler, Quinton" sort="Katler, Quinton" uniqKey="Katler Q" first="Quinton" last="Katler">Quinton Katler</name></noRegion><name sortKey="Kawwass, Jennifer F" sort="Kawwass, Jennifer F" uniqKey="Kawwass J" first="Jennifer F." last="Kawwass">Jennifer F. 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